Antibiotic resistance often confers a fitness cost to the resistant cell and thus raises key
questions of how resistance is maintained in the absence of antibiotics and, if lost, whether …

Global spread of multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages
underscores the need for new therapeutic strategies. Here we show that many S …

The ability of Staphylococcus aureus to colonise different niches across the human body is
linked to an adaptable metabolic capability, as well as its ability to persist within specific …

Following the completion of an adaptive evolution experiment, fitness evaluations are
routinely conducted to assess the magnitude of adaptation. In doing so, proper …

The emergence of antibiotic-resistant and biofilm-producing Staphylococcus aureus isolates
presents major challenges for treating staphylococcal infections. Biofilm inhibition is an …

Vancomycin and daptomycin are first-line drugs for the treatment of complicated methicillin-
resistant Staphylococcus aureus (MRSA) infections, including bacteremia. However, their …

As the availability of data sets increases, meta-analysis leveraging aggregated and
interoperable data types is proving valuable. This study leveraged a meta-analysis workflow …

Staphylococcus aureus causes serious clinical infections, including bacteremia and
endocarditis. When clinicians suspect these diseases, they prescribe broad-spectrum …

Among the 16 two-component systems (TCSs) in the opportunistic human pathogen
Staphylococcus aureus, only WalKR is essential. Like orthologous systems in other …

We report the case of a patient with infective endocarditis on a prosthetic aortic valve due to
Staphylococcus epidermidis, not a candidate for prosthetic replacement surgery. After three …