Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

The mediodorsal thalamus (MD) shares reciprocal connectivity with the prefrontal cortex
(PFC), and decreased MD–PFC connectivity is observed in schizophrenia patients. Patients …

Psychedelics exert unique effects on human consciousness. The thalamic filter model
suggests that core effects of psychedelics may result from gating deficits, based on a …

The transdiagnostic expression of psychotic experiences in common mental disorder
(anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a …

Infancy is a critical and immensely important period in human brain development. Subtle
changes during this stage may be greatly amplified with the unfolding of different …

Deficits in cognition are a core feature of many psychiatric conditions, including
schizophrenia, where the severity of such deficits is a strong predictor of long-term outcome …

Understanding the fundamental alterations in brain functioning that lead to psychotic
disorders remains a major challenge in clinical neuroscience. In particular, it is unknown …

Scientific progress in understanding human disease can be measured by the effectiveness
of its treatment. Antipsychotic drugs have been proven to alleviate acute psychotic symptoms …

Although cerebellar involvement across a wide range of cognitive and neuropsychiatric
phenotypes is increasingly being recognized, previous large-scale studies in schizophrenia …