Acute pain induces depressed mood, and chronic pain is known to cause depression.
Depression, meanwhile, can also adversely affect pain behaviors ranging from …

▪ Abstract The issue of whether pain is represented by specific neural elements or by
patterned activity within a convergent somatosensory subsystem has been debated for over …

Rumination is a form of thought characterized by repetitive focus on discomforting emotions
or stimuli. In chronic pain disorders, rumination can impede treatment efficacy. The brain …

The insula is anatomically situated to be critically involved in many bio-behavioral functions
impaired in schizophrenia. Furthermore, its total volume has been shown to be reduced in …

It is common clinical experience that anxiety about pain can exacerbate the pain sensation.
Using event-related functional magnetic resonance imaging (FMRI), we compared activation …

Context Psychopaths belong to a larger group of persons with antisocial personality disorder
and are characterized by an inability to have emotional involvement and by the repeated …

Background Besides chronic stress, chronic pain is a prevalent determinant for depression.
Changes induced in specific brain regions by sustained pain may alter the processing of …

Romantic rejection causes a profound sense of loss and negative affect. It can induce
clinical depression and in extreme cases lead to suicide and/or homicide. To begin to …

Only recently have neuroimaging studies moved away from describing regions activated by
noxious stimuli and started to disentangle subprocesses within the nociceptive system. One …

Functional imaging techniques have allowed researchers to look within the brain, and
revealed the cortical representation of pain. Initial experiments, performed in the early …