Long noncoding RNA lncARSR promotes nonalcoholic fatty liver disease and hepatocellular carcinoma by promoting YAP1 and activating the IRS2/AKT pathway

Y Chi, Z Gong, H Xin, Z Wang, Z Liu - Journal of translational medicine, 2020 - Springer
Background Nonalcoholic fatty liver disease (NAFLD) is the main cause for hepatocellular
carcinoma (HCC). This study was intended to identify the function of long non-coding RNA …

Structural characterization of Euglena gracilis polysaccharide and its in vitro hypoglycemic effects by alleviating insulin resistance

X Huang, Y Wen, Y Chen, Y Liu, C Zhao - International Journal of …, 2023 - Elsevier
Diabetes mellitus, characterized by hyperglycemia and insulin resistance, is a disorder of
the endocrine metabolic system which has emerged as a common chronic disease …

Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies

SW Yee, D Buitrago, A Stecula, HX Ngo… - The FASEB …, 2020 - Wiley Online Library
The human solute carrier 22A (SLC22A) family consists of 23 members, representing one of
the largest families in the human SLC superfamily. Despite their pharmacological and …

Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1

L Zhou, C Zhang, X Yang, L Liu, J Hu… - Clinical and …, 2021 - Wiley Online Library
Background Androgen deprivation therapy (ADT) is the main clinical treatment for patients
with advanced prostate cancer (PCa). However, PCa eventually progresses to castration …

The Roles of Imprinted SLC22A18 and SLC22A18AS Gene Overexpression Caused by Promoter CpG Island Hypomethylation as Diagnostic and Prognostic …

JF Noguera-Uclés, L Boyero, A Salinas… - Cancers, 2020 - mdpi.com
Genomic imprinting is a process that involves one gene copy turned-off in a parent-of-origin-
dependent manner. The regulation of imprinted genes is broadly dependent on promoter …

Modeling allele-specific expression at the gene and SNP levels simultaneously by a Bayesian logistic mixed regression model

J Xie, T Ji, MAR Ferreira, Y Li, BN Patel, RM Rivera - BMC bioinformatics, 2019 - Springer
Background High-throughput sequencing experiments, which can determine allele origins,
have been used to assess genome-wide allele-specific expression. Despite the amount of …

Analysis of SLC genes alternative splicing identifies the SLC7A6 RI isoform as a therapeutic target for colorectal cancer

C Sun, B Zeng, J Zhou, N Li, M Li, C Zhu, S Xie… - Cancer …, 2025 - Wiley Online Library
Alternative splicing (AS), a crucial mechanism in post‐transcriptional regulation, has been
implicated in diverse cancer processes. Several splicing variants of solute carrier (SLC) …

New insights in equine steroidogenesis: an in-depth look at steroid signaling in the placenta

SC Loux, AJ Conley, KE Scoggin, HES Ali… - …, 2020 - rep.bioscientifica.com
Steroid production varies widely among species, with these differences becoming more
pronounced during pregnancy. As a result, each species has its own distinct pattern of …

[HTML][HTML] Overexpression of Slc22a18 facilitates fat accumulation in mice

T Yamamoto, Y Iizuka, K Izumi-Yamamoto… - Biochemical and …, 2024 - Elsevier
We previously reported that solute carrier family 22 member 18 (Slc22a18) regulates lipid
accumulation in 3T3-L1 adipocytes. Here, we provide additional evidence derived from …

Hepatic drug-metabolizing enzymes and drug transporters in Wilson's disease patients with liver failure

S Szeląg-Pieniek, S Oswald, M Post… - Pharmacological …, 2021 - Springer
Background Wilson's disease is a genetic disorder inherited in a recessive manner, caused
by mutations in the copper-transporter ATP7B. Although it is a well-known disease, currently …