The general notion of an “RNA world” is that, in the early development of life on the Earth,
genetic continuity was assured by the replication of RNA, and RNA molecules were the chief …

Living and proliferating cells undergo repeated cycles of growth, replication and division, all
orchestrated by complex molecular networks. How a minimal cell cycle emerged and helped …

A key challenge in origin-of-life research is the identification of plausible conditions that
facilitate multiple steps along the pathway from chemistry to biology. The incompatibility of …

Nonenzymatic template-directed RNA copying using chemically activated nucleotides is
thought to have played a key role in the emergence of genetic information on the early Earth …

We propose a model for the replication of primordial protocell genomes that builds upon
recent advances in the nonenzymatic copying of RNA. We suggest that the original …

The chemical replication of RNA inside fatty acid vesicles is a plausible step in the
emergence of cellular life. On the primitive Earth, simple protocells with the ability to import …

The emergence of the replication of RNA oligonucleotides was a critical step in the origin of
life. An important model for the study of nonenzymatic template copying, which would be a …

The identification of nonenzymatic pathways for nucleic acid replication is a key challenge in
understanding the origin of life. We have previously shown that nonenzymatic RNA primer …

The non‐enzymatic replication of the primordial genetic material is thought to have enabled
the evolution of early forms of RNA‐based life. However, the replication of oligonucleotides …

The nonenzymatic copying of RNA is thought to have been necessary for the transition
between prebiotic chemistry and ribozyme-catalyzed RNA replication in the RNA World. We …