One of the most crucial parameters in protein crystallization is pH, as it governs the protein's
electrostatic interactions. However, the fundamental role of pH on crystallization still remains …

Protein therapeutics have a major role in medicine in that they are used to treat diverse
pathologies. Their three-dimensional structures not only offer higher specificity and lower …

Pulmonary delivery of insulin in the form of a dry powder is an attractive alternative in
comparison to conventional subcutaneous delivery. Insulin crystals have potential …

Amino acids have been widely used in protein formulations to increase the protein's stability.
In this study, amino acids have been introduced as soft-templates to control the nucleation of …

Although the Classical Nucleation Theory (CNT) is the most consensual theory to explain
protein nucleation mechanisms, experimental observations during the shear-induced …

Although half a century has passed since the mapping of the insulin structure, this globular
protein is still currently being investigated. Crystalline drug formulations might replace the …

Insulin is a human therapeutic protein that has been used to treat diabetes for almost a
century. Its crystallization has been of significant interest since the protein is commonly …

Protein crystallization can represent a viable alternative to conventional protein separation
and purification methods. However, the stochastic nature of the nucleation step as well as …

The development of the first microfluidic prototype appeared at the beginning of the 1980s.
However, over the last decade, droplet-based microfluidics has emerged as a powerful tool …

Self-assembly is the process in which the constitutive components of a system
spontaneously organize into ordered patterns or structures driven by non-covalent …