Abstract Background Knowledge about Klinefelter syndrome (KS) has increased
substantially since its first description almost 80 years ago. A variety of treatment options …

To achieve a balanced gene expression dosage between males (XY) and females (XX),
mammals have evolved a compensatory mechanism to randomly inactivate one of the …

The study of sexual dimorphism in psychiatric and neurodevelopmental disorders is
challenging due to the complex interplay of diverse biological, psychological, and social …

Klinefelter syndrome (KS) is the most frequent chromosome disorder in males (1: 650
newborn males), defined by 47, XXY karyotype. The classical phenotype is that of a tall male …

The male predominance of Autism Spectrum Disorders (ASD) is one of the best-known, and
at the same time, one of the least understood characteristics of these disorders. In this paper …

X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random
silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon …

We provide an in-depth review of the role of androgens in male maturation and
development, from the fetal stage through adolescence into emerging adulthood, and …

The research field of SCT is in need of a more longitudinal perspective to identify early
markers of 'at risk'development, and to assess the effectiveness of early interventions …

Objectives To examine the effects of early low-dose androgen on motor, cognitive, and
behavioral function in prepubertal boys with Klinefelter syndrome (47, XXY). Study design …

Neuroimaging studies have shown that having an extra X chromosome is associated with
abnormal structure and function of brain areas in the frontal lobe, which is crucially involved …