Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …

Aspergilli produce conidia for reproduction or to survive hostile conditions, and they are
highly effective in the distribution of conidia through the environment. In …

Fungal infections are a universal problem and are routinely associated with high morbidity
and mortality rates in immunocompromised patients. Existing therapies comprise five …

The incidence of invasive fungal infections has risen dramatically in recent decades. Current
antifungal drugs are either toxic, likely to interact with other drugs, have a narrow spectrum …

Amphotericin B (AmB) is the antifungal with the strongest fungicidal activity, but its use has
several limitations, mainly associated with its toxicity. Although some lipidic and liposomal …

Ergosterol is a major and specific component of the fungal plasma membrane, and thus, the
cytochrome P450 enzymes (Erg proteins) that catalyze ergosterol synthesis have been …

Filamentous and dimorphic fungi cause invasive mycoses associated with high mortality
rates. Among the fungal determinants involved in the establishment of infection …

The incidence of invasive fungal infections is rising due to the increase in susceptible
populations. Current clinically available drugs have therapeutic limitations due to toxicity, a …

Therapeutic strategies against systemic mycoses can involve antifungal resistance and
significant toxicity. Thus, novel therapeutic approaches to fight fungal infections are urgent …

Phosphatidylinositol phosphates are key phospholipids with a range of regulatory roles,
including membrane trafficking and cell polarity. Phosphatidylinositol-4-phosphate [PI (4) P] …