Alkaloids are one of the most important classes of plant bioactives. Among these
isoquinoline alkaloids possess varied structures and exhibit numerous biological activities …

Complex diseases such as neurodegenerative disorders and cancer constitute a growing
public health problem due to the rising incidence and lack in effective therapies. Since …

Spinal cord injury (SCI) causes immune activation of resident macrophages/microglia.
Activated macrophages/microglia have two different phenotypes, the pro-inflammatory …

Inflammation is an adaptive response of the immune system to tissue malfunction or
homeostatic imbalance. Corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) …

The direct functionalization of inert C (sp3)− H bonds under environmentally benign catalytic
conditions remains a challenging task in synthetic chemistry. Here, we report an …

Conspectus The naphthylisoquinoline (NIQ) alkaloids are a thrilling class of natural biaryls─
structurally, biosynthetically, and pharmacologically. A common feature of these metabolites …

Inflammation occurs when the immune system responses to external harmful stimuli and
infection. Chronic inflammation induces various diseases. A variety of foods are prescribed …

The novel coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), which initially appeared in Wuhan, China, in …

Accelerated biological aging, which involves the gradual decline of organ or tissue functions
and the distortion of physiological processes, underlies several human diseases. Away from …

Background Cancer is the most common cause of death and is still a serious public health
problem. Alkaloids, a class of bioactive compounds widely diffused in plants, especially …