Aza-derivatives of phenols such as Schiff bases and hydrazones are an important and
interesting group of chemical compounds. They exhibit a number of biological activities and …

Introduction: Programmed cell death is well-orchestrated process regulated by multiple pro-
apoptotic and anti-apoptotic genes, particularly those of the Bcl-2 gene family. These genes …

Gossypol, a complex polyphenolic compound, is a naturally occurring highly colored yellow
pigment found in the small intercellular pigment glands in the leaves, stems, roots, and seed …

Introduction: The B-cell lymphoma-2 (Bcl-2) family of proteins is central to the regulation of
apoptosis, which is vital for proper tissue development and cellular homeostasis. Anti …

A critical regulator of the apoptotic machinery is the Bcl‐2 family proteins whose over
expression confers a protective effect on malignant cells against death signals of apoptosis …

Introduction: Bcl-2 family proteins are a component of the antiapoptotic machinery and are
overexpressed in different malignancies. Accordingly, their enhanced expression has been …

Gossypol, a constituent of cottonseeds, displays various drug properties, including
antifertility and anticancer. Toxicity is shown against the reproductive system, heart, liver …

A series of amino acid gossypol Schiff bases were designed, synthesized and evaluated for
their anti-TMV activities, and a new method of preparing hydrophilic amino acid gossypol …

Interest in the mechanisms of DNA repair pathways, including the base excision repair
(BER) pathway specifically, has heightened since these pathways have been shown to …

A Schiff base of gossypol with 3, 6, 9, 12, 15, 18, 21, 24‐octaoxa‐pentacosylamine (GSOB)
forms stable complexes with monovalent cations. This process of complex formation was …