The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

X He, Y Li, B Deng, A Lin, G Zhang, M Ma… - Cell …, 2022 - Wiley Online Library
Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

COVID-19 and cognitive impairment: neuroinvasive and blood‒brain barrier dysfunction

Y Chen, W Yang, F Chen, L Cui - Journal of Neuroinflammation, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has led to a global pandemic. Although COVID-19 …

Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation

ZI Kovacs, S Kim, N Jikaria, F Qureshi… - Proceedings of the …, 2017 - National Acad Sciences
MRI-guided pulsed focused ultrasound (pFUS) combined with systemic infusion of
ultrasound contrast agent microbubbles (MB) causes localized blood–brain barrier (BBB) …

[HTML][HTML] A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt (Ser473)/GSK3β (Ser9)-mediated …

S Liao, J Wu, R Liu, S Wang, J Luo, Y Yang, Y Qin, T Li… - Redox biology, 2020 - Elsevier
Microglia-mediated neuroinflammation plays a crucial role in the pathophysiological process
of multiple neurological disorders such as ischemic stroke, yet lacks effective therapeutic …

[HTML][HTML] Blood-brain barrier leakage in Alzheimer's disease: From discovery to clinical relevance

G Nehra, B Bauer, AMS Hartz - Pharmacology & therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

Blood-brain barrier tight junction permeability and ischemic stroke

KE Sandoval, KA Witt - Neurobiology of disease, 2008 - Elsevier
The blood-brain barrier (BBB) is formed by the endothelial cells of cerebral microvessels,
providing a dynamic interface between the peripheral circulation and the central nervous …

The janus face of VEGF in stroke

SJ Geiseler, C Morland - International journal of molecular sciences, 2018 - mdpi.com
The family of vascular endothelial growth factors (VEGFs) are known for their regulation of
vascularization. In the brain, VEGFs are important regulators of angiogenesis …

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

DM Hermann, M Chopp - The Lancet Neurology, 2012 - thelancet.com
Recent laboratory findings suggest that it might be possible to promote cerebral plasticity
and neurological recovery after stroke by use of exogenous pharmacological or cell-based …

Inflammation-mediated angiogenesis in ischemic stroke

H Zhu, Y Zhang, Y Zhong, Y Ye, X Hu, L Gu… - Frontiers in Cellular …, 2021 - frontiersin.org
Stroke is the leading cause of disability and mortality in the world, but the pathogenesis of
ischemic stroke (IS) is not completely clear and treatments are limited. Mounting evidence …

Role and therapeutic potential of VEGF in the nervous system

C Ruiz de Almodovar, D Lambrechts… - Physiological …, 2009 - journals.physiology.org
The development of the nervous and vascular systems constitutes primary events in the
evolution of the animal kingdom; the former provides electrical stimuli and coordination …