Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European …

Background: Due to the rapidly escalating number of cases and the low baseline of overall
health in Louisiana, we sought to determine the prognostic value of the neutrophil-to …

T lymphocytes, from their first encounter with their specific antigen as naïve cell until the last
stages of their differentiation, in a replicative state of senescence, go through a series of …

Sepsis results in a deluge of pro-and anti-inflammatory cytokines, leading to lymphopenia
and chronic immunoparalysis. Sepsis-induced long-lasting immunoparalysis is defined, in …

Sepsis represents a life-threatening organ dysfunction due to an aberrant host response. Of
note is that majority of patients have experienced a severe immune depression during and …

Cytokines play a critical role in coordinating and amplifying a host immune response to
infection. The normal pattern of localized and systemic release of proinflammatory and anti …

Microbial exposures can define an individual's basal immune state. Cohousing specific
pathogen-free (SPF) mice with pet store mice, which harbor numerous infectious microbes …

This narrative review provides an overview of the evolving significance of lymphopenia in
sepsis, emphasizing its critical function in this complex and heterogeneous disease. We …