Animal models of obesity and diabetes mellitus
More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …
Branched chain amino acids, aging and age-related health
Branched chain amino acids (BCAA: leucine, valine, isoleucine) have key physiological
roles in the regulation of protein synthesis, metabolism, food intake and aging. Many studies …
roles in the regulation of protein synthesis, metabolism, food intake and aging. Many studies …
[HTML][HTML] Individual cell types in C. elegans age differently and activate distinct cell-protective responses
Aging is characterized by a global decline in physiological function. However, by
constructing a complete single-cell gene expression atlas, we find that Caenorhabditis …
constructing a complete single-cell gene expression atlas, we find that Caenorhabditis …
Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria
Metabolic dysfunction occurs in many age-related neurodegenerative diseases, yet its role
in disease etiology remains poorly understood. We recently discovered a potential causal …
in disease etiology remains poorly understood. We recently discovered a potential causal …
SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion
KA Anderson, FK Huynh, K Fisher-Wellman, JD Stuart… - Cell metabolism, 2017 - cell.com
Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of
metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic …
metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic …
Mitochondrial dysfunction, insulin resistance, and potential genetic implications: potential role of alterations in mitochondrial function in the pathogenesis of insulin …
P Sangwung, KF Petersen, GI Shulman… - …, 2020 - academic.oup.com
Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D) and is
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …
Dissecting aging and senescence—current concepts and open lessons
C Schmeer, A Kretz, D Wengerodt, M Stojiljkovic… - Cells, 2019 - mdpi.com
In contrast to the programmed nature of development, it is still a matter of debate whether
aging is an adaptive and regulated process, or merely a consequence arising from a …
aging is an adaptive and regulated process, or merely a consequence arising from a …
TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging
TK Blackwell, AK Sewell, Z Wu, M Han - Genetics, 2019 - academic.oup.com
The T arget of R apamycin (TOR or mTOR) is a serine/threonine kinase that regulates
growth, development, and behaviors by modulating protein synthesis, autophagy, and …
growth, development, and behaviors by modulating protein synthesis, autophagy, and …
L-threonine promotes healthspan by expediting ferritin-dependent ferroptosis inhibition in C. elegans
The pathways that impact longevity in the wake of dietary restriction (DR) remain still ill-
defined. Most studies have focused on nutrient limitation and perturbations of energy …
defined. Most studies have focused on nutrient limitation and perturbations of energy …
Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and …
L Zhang, J Han - Biochemical and biophysical research communications, 2017 - Elsevier
Branched-chain amino acids (BCAAs) are important nutrient signals that have direct and
indirect effects. BCAA catabolism is a conserved regulator of physiological aging and …
indirect effects. BCAA catabolism is a conserved regulator of physiological aging and …