Enantiomers, where chirality arises from restricted rotation around a single bond, are
atropisomers. Due to the unique nature of the origins of their chirality, synthetic strategies to …

Transition metal-mediated C–H bond activation and functionalization represent one of the
most straightforward and powerful tools in modern organic synthetic chemistry. Bi (hetero) …

The chemistry of copper is extremely rich because it can easily access Cu0, CuI, CuII, and
CuIII oxidation states allowing it to act through one-electron or two-electron processes. As a …

Does the dehydrogenative coupling of aromatic compounds mediated by AlCl3 at high
temperatures and also by FeCl3, MoCl5, PIFA, or K3 [Fe (CN) 6] at room temperature …

Atroposelective synthesis of axially chiral biaryls by palladium‐catalyzed C− H olefination,
using tert‐leucine as an inexpensive, catalytic, and transient chiral auxiliary, has been …

The selective oxidation of C H bonds and the use of O2 as a stoichiometric oxidant
represent two prominent challenges in organic chemistry. Copper (II) is a versatile oxidant …

Intellectual curiosity has always been one of the major driving forces leading to new
advances in chemistry. At the onset of the 20th century, the fact that biaryls could be optically …

Natural product synthesis is a highly demanding field in constant need of efficient
transformations that allow either straightforward, scalable, and high-yielding preparation of …

A rotationally hindered and thus stereogenic biaryl axis is the structurally and
stereochemically decisive element of a steadily growing number of natural products, chiral …

This tutorial review highlights the use of catalytic asymmetric 2-naphthol couplings in total
synthesis. The types of chirality, chiral biaryl natural products, prior approaches to chiral …