Interstitial cells: regulators of smooth muscle function

KM Sanders, SM Ward, SD Koh - Physiological reviews, 2014 - journals.physiology.org
Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells.
Interstitial cells of mesenchymal origin interact with and form electrical connectivity with …

Interstitial Cajal‐like cells in human uterus and fallopian tube

LM Popescu, SM Ciontea… - Annals of the New York …, 2007 - Wiley Online Library
Recently, parallels have been drawn between enteric interstitial cells of Cajal (ICC) and
similar cells outside the gut—interstitial Cajal‐like cells (ICLC). This article reviews our …

Altered expression of interstitial cells of Cajal in congenital ureteropelvic junction obstruction

V Solari, AP Piotrowska, P Puri - The Journal of urology, 2003 - Elsevier
PURPOSE: Peristaltic contractions in the upper urinary tract serve to move urine from the
kidney through the ureter to the bladder. Ureteropelvic junction (UPJ) obstruction is the most …

C‐kit immunopositive interstitial cells (Cajal‐type) in human myometrium

SM Ciontea, E Radu, T Regalia… - Journal of cellular …, 2005 - Wiley Online Library
Previous reports describing Cajal‐like interstitial cells in human uterus are contradictory in
terms of c‐kit immunoreactivity: either negative (but vimentin‐positive) in pregnant …

Novel type of interstitial cell (Cajal‐like) in human fallopian tube

LM Popescu, SM Ciontea, D Cretoiu… - Journal of cellular …, 2005 - Wiley Online Library
We describe here‐presumably for the first time‐a Cajal‐like type of tubal interstitial cells (t‐
ICC), resembling the archetypal enteric ICC. t‐ICC were demonstrated in situ and in vitro on …

Interstitial cells of Cajal: a new perspective on smooth muscle function

KM Sanders, SM Ward - The Journal of physiology, 2006 - Wiley Online Library
Interstitial cells of Cajal (ICC) were described more than 100 years ago by Ramon y Cajal.
For many years these cells were identified only by non‐specific histological stains and later …

Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal‐like cells as pacemakers

RJ Lang, MA Tonta, BZ Zoltkowski… - The Journal of …, 2006 - Wiley Online Library
Pyeloureteric peristalsis has long been considered to be triggered by pacemaker atypical
smooth muscle cells (SMC) located in the proximal regions of the renal pelvis. However …

The functional effects of ac‐kit tyrosine inhibitor on guinea‐pig and human detrusor

SM Biers, JM Reynard, T Doore, AF Brading - BJU international, 2006 - Wiley Online Library
OBJECTIVE To describe the effect of a specific c‐kit receptor inhibitor (imatinib mesylate) on
human detrusor strips in vitro and guinea‐pig cystometry in vivo, and to show histological …

Myometrial interstitial cells and the coordination of myometrial contractility

G Hutchings, O Williams, D Cretoiu… - Journal of cellular and …, 2009 - Wiley Online Library
Introduction• Nomenclature• Uterine contractions and the 'functional syncytium theory'•
Interstitial cells of Cajal in the gastrointestinal and urinary tracts• Are there m‐ICLC in …

Novel drug targets for the pharmacotherapy of benign prostatic hyperplasia (BPH)

S Ventura, VL Oliver, CW White, JH Xie… - British journal of …, 2011 - Wiley Online Library
Benign prostatic hyperplasia (BPH) is the major cause of lower urinary tract symptoms in
men aged 50 or older. Symptoms are not normally life threatening, but often drastically affect …