Syncytia are formed when individual cells fuse. SARS-CoV-2 induces syncytia when the
viral spike (S) protein on the surface of an infected cell interacts with receptors on …

Interferon-induced transmembrane proteins (IFITMs) are broad spectrum antiviral factors that
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …

The cellular entry of severe acute respiratory syndrome-associated coronaviruses types 1
and 2 (SARS-CoV-1 and-2) requires sequential protease processing of the viral spike …

The host innate immune response mediated by type I interferon (IFN) and the resulting up-
regulation of hundreds of interferon-stimulated genes (ISGs) provide an immediate barrier to …

Animal cells use a wide variety of mechanisms to slow or prevent replication of viruses.
These mechanisms are usually mediated by antiviral proteins whose expression and …

Vesicle-membrane-protein-associated protein A (VAPA) and oxysterol-binding protein
(OSBP) regulate intracellular cholesterol homeostasis, which is required for many virus …

Interferon-induced transmembrane proteins (IFITMs) are a family of small proteins that
localize in the plasma and endolysosomal membranes. IFITMs not only inhibit viral entry into …

Transcriptional enhancers are critical for maintaining cell-type–specific gene expression and
driving cell fate changes during development. Highly transcribed genes are often associated …

The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of
pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and …

Interferon‐inducible transmembrane (IFITM) proteins are a family of small homologous
proteins, localized in the plasma and endolysosomal membranes, which confer cellular …