The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine
S Iyengar, MH Ossipov, KW Johnson - Pain, 2017 - journals.lww.com
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
Nerve growth factor signaling and its contribution to pain
Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …
and survival of sympathetic and sensory afferent neurons during development. A substantial …
Fremanezumab—a humanized monoclonal anti-CGRP antibody—inhibits thinly myelinated (Aδ) but not unmyelinated (C) meningeal nociceptors
Calcitonin gene-related peptide (CGRP), the most abundant neuropeptide in primary
afferent sensory neurons, is strongly implicated in the pathophysiology of migraine …
afferent sensory neurons, is strongly implicated in the pathophysiology of migraine …
Dual therapy with anti‐CGRP monoclonal antibodies and botulinum toxin for migraine prevention: is there a rationale?
Objective To narratively review the pathophysiological rationale of dual therapy with anti‐
calcitonin gene‐related peptide monoclonal antibodies and botulinum toxin type A in …
calcitonin gene‐related peptide monoclonal antibodies and botulinum toxin type A in …
The role of peptides in central sensitization
VS Seybold - Sensory Nerves, 2009 - Springer
Peptides released in the spinal cord from the central terminals of nociceptors contribute to
the persistent hyperalgesia that defines the clinical experience of chronic pain. Using …
the persistent hyperalgesia that defines the clinical experience of chronic pain. Using …
Calcitonin gene‐related peptide (CGRP) and migraine current understanding and state of development
ME Bigal, S Walter, AM Rapoport - Headache: The Journal of …, 2013 - Wiley Online Library
Calcitonin gene‐related peptide (CGRP) is a ubiquitous neuropeptide found at the very
centers of the migraine process, both centrally and peripherally. It has been under careful …
centers of the migraine process, both centrally and peripherally. It has been under careful …
Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain
The prevalence and severity of many chronic pain syndromes differ across sex, and recent
studies have identified differences in immune signalling within spinal nociceptive circuits as …
studies have identified differences in immune signalling within spinal nociceptive circuits as …
Gait analysis and pain response of two rodent models of osteoarthritis
The purpose of this study was to compare the gait parameters recorded on the CatWalk and
the mechanical sensitivity with von Frey filaments of two putative models of osteoarthritis …
the mechanical sensitivity with von Frey filaments of two putative models of osteoarthritis …
PI3K/Akt pathway: a potential therapeutic target for chronic pain
SP Chen, YQ Zhou, DQ Liu, W Zhang… - Current …, 2017 - ingentaconnect.com
Chronic pain is among the most disabling and costly disorders, with prevalence ranging
from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory …
from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory …
Spinal phosphinositide 3-Kinase–Akt–Mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia
Q Xu, B Fitzsimmons, J Steinauer, A O'Neill… - Journal of …, 2011 - Soc Neuroscience
Phosphinositide 3-kinase (PI3K), Akt, and their downstream kinase, mammalian target of
rapamycin (mTOR), are implicated in neural plasticity. The functional linkages of this …
rapamycin (mTOR), are implicated in neural plasticity. The functional linkages of this …