Plasmodium sporozoites are the product of a complex developmental process in the
mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to …

The mosquito midgut stages of malaria parasites are crucial for establishing an infection in
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …

INTRODUCTION Plasmodium parasites, the causative agent of malaria, are single-celled
organisms with distinct morphological developmental stages each specialized to inhabit …

The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …

The invasive stages (zoites) of most apicomplexan parasites are polarised cells that use
their actinomyosin-powered gliding motility or “glideosome” system to move over surfaces …

The causative agent of malaria, Plasmodium, has to undergo complex developmental
transitions and survive attacks from the mosquito's innate immune system to achieve …

Gene expression in Plasmodium parasites undergoes significant changes in each
developmental stage, but the transcription factors (TFs) regulating these changes have not …

The genome-wide identification of gene functions in malaria parasites is hampered by a lack
of reverse genetic screening methods. We present a large-scale resource of barcoded …

The malarial sporozoite is the stage that infects the liver, and genes expressed in this stage
are potential targets for vaccine development. Here, we demonstrate that specific gene …

The sexual phase of the malaria pathogen, Plasmodium falciparum, culminates in
fertilization within the midgut of the mosquito and represents a crucial step in the completion …