Autophagy is a conserved multistep pathway that degrades and recycles damaged
organelles and macromolecules to maintain intracellular homeostasis. The autophagy …

AKI is a common clinical condition associated with the risk of developing CKD and ESKD.
Sepsis is the leading cause of AKI in the intensive care unit (ICU) and accounts for nearly …

Autophagy, an evolutionary conserved intracellular lysosome-dependent catabolic process,
is an important mechanism for cellular homeostasis and survival during pathologic stress …

Background Renal ischemia-reperfusion injury (IRI) increases the rates of acute kidney
failure, delayed graft function, and early mortality after kidney transplantation. The …

Inflammation and oxidative stress are the main pathological processes that accompany
ischemic injury of kidneys and other organs. Based on this, these factors are often chosen as …

Inhibitors of mammalian target of rapamycin (mTOR) have immunosuppressive and anti-
cancer effects, but their effects on the progression of kidney disease are not fully understood …

The main side effect of cyclosporine A (CsA), a widely used immunosuppressive drug, is
nephrotoxicity. Early detection of CsA-induced acute nephrotoxicity is essential for stop or …

Aim Ischemia reperfusion injury (IRI) is a leading cause of acute kidney injury, which is
associated with high morbidity. The aims of the present study were to examine whether …

Background/Aims: Reactive oxygen species play an important role in the pathogenesis of
kidney ischemia/reperfusion injury (IRI) which may be influenced by immunosuppressive …

The mTOR signaling pathway plays a crucial role in the regulation of cell growth,
proliferation, survival and in directing immune responses. As the intestinal epithelium …