The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

1. INTRODUCTION The length of straightened-out DNA in a single cell is nearly 2 m. In
mammalian cells, the nucleus has a diameter of approximately 6 μm and occupies about …

A series of novel terpyridine-skeleton molecules containing conformational rigidity, 14
containing benzo [4, 5] furo [3, 2-b] pyridine core and 15 comprising chromeno [4, 3-b] …

DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …

DNA topoisomerases comprise a major aspect of basic cellular biology and are molecular
targets for a variety of drugs like antibiotics, antibacterials and anticancer drugs. They act by …

The reaction of one equivalents of 5‐acetylthiadiazole with one equivalent of aldehyde in
acetic acid and ammonium acetate yielded thiadiazolyl‐pyridine derivatives in a …

A new series of 2, 4-diphenyl-6-aryl pyridines containing hydroxyl group (s) at the ortho,
meta, or para position of the phenyl ring were synthesized, and evaluated for topoisomerase …

We have designed and synthesized a series of 2, 4, 6-triaryl pyridine derivatives containing
chlorophenyl and phenolic moeity at 2-and 4-position of the central pyridine, respectively …

Pyridine, 1, 3, 4-thiadiazole, and 1, 3-thiazole derivatives have various biological activities,
such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other …

Twelve dihydroxylated 2, 4, 6-triphenyl pyridines were designed and synthesized which
contain hydroxyl groups at ortho, meta or para position of 2-and 6-phenyl, or 2-and 4-phenyl …