Engineered nanoparticles for clinical assays

J Cheong, A Jo, J Lee, S Lee, J Lee, JH Lee… - Nature Reviews …, 2024 - nature.com
Nanoparticles exhibit distinctive physical and chemical properties that make them effective
mediators for optical, magnetic or electric signal transduction. Consequently, nanoparticles …

Nucleic Acid Amplification-Free Digital Detection Method for SARS-CoV-2 RNA Based on Droplet Microfluidics and CRISPR–Cas13a

X Shan, F Gong, Y Yang, J Qian, Z Tan, S Tian… - Analytical …, 2023 - ACS Publications
Most of the methods currently developed for RNA detection based on CRISPR were
combined with nucleic acid amplification. As a result, such methods inevitably led to certain …

Development of a New Lab-on-Paper Microfluidics Platform Using Bi-Material Cantilever Actuators for ELISA on Paper

H Heidari-Bafroui, A Kumar, C Hahn, N Scholz… - Biosensors, 2023 - mdpi.com
In this paper, we present a novel and cost-effective lab-on-paper microfluidics platform for
performing ELISA autonomously, with no user intervention beyond adding the sample. The …

Shifting the paradigm in RNA virus detection: integrating nucleic acid testing and immunoassays through single-molecule digital ELISA

Z Wang, P Wei - Frontiers in Immunology, 2024 - frontiersin.org
In this review article, we explore the characteristics of RNA viruses and their potential threats
to humanity. We also provide a brief overview of the primary contemporary techniques used …

[HTML][HTML] Bead-based microfluidic platforms for multiplex and ultrasensitive immunoassays in clinical diagnosis and treatment

X Fang, Y Yang, H Wang, H Xu - Mechanobiology in Medicine, 2024 - Elsevier
Multiplex ultrasensitive detection of low abundance proteins remains a significant challenge
in clinical applications, necessitating the development of innovative solutions. The …

Nucleic Acid Target Sensing Using a Vibrating Sharp-Tip Capillary and Digital Droplet Loop-Mediated Isothermal Amplification (ddLAMP)

BJ Fike, K Curtin, P Li - Sensors, 2024 - mdpi.com
Nucleic acid tests are key tools for the detection and diagnosis of many diseases. In many
cases, the amplification of the nucleic acids is required to reach a detectable level. To make …

Displacement Mapping as a Highly Flexible Surface Texturing Tool for Additively Photopolymerized Components

R Bail, DH Lee - Micromachines, 2024 - mdpi.com
Displacement mapping is a computer graphics technique that enables the design of
components with regularly or randomly textured surfaces that can be quickly materialized on …

[图书][B] Microfluidic Paper-Based Devices for the Detection of Chemical and Biological Agents

H Heidaribafroui - 2023 - search.proquest.com
This work was motivated by two needs: to develop low-cost, high-sensitivity, and accurate
systems for detecting phosphate in seawater, and to create a platform technology by …