Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

S Qin, W Xiao, C Zhou, Q Pu, X Deng, L Lan… - Signal transduction and …, 2022 - nature.com
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design

G Bahr, LJ Gonzalez, AJ Vila - Chemical reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Biological properties of extracellular vesicles and their physiological functions

M Yáñez-Mó, PRM Siljander, Z Andreu… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

A novel mechanism of host-pathogen interaction through sRNA in bacterial outer membrane vesicles

K Koeppen, TH Hampton, M Jarek, M Scharfe… - PLoS …, 2016 - journals.plos.org
Bacterial outer membrane vesicle (OMV)-mediated delivery of proteins to host cells is an
important mechanism of host-pathogen communication. Emerging evidence suggests that …

Cystic fibrosis: a mucosal immunodeficiency syndrome

TS Cohen, A Prince - Nature medicine, 2012 - nature.com
Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that
regulates the transport of ions and the movement of water across the epithelial barrier …

Contact lens-related corneal infection: Intrinsic resistance and its compromise

SMJ Fleiszig, AR Kroken, V Nieto, MR Grosser… - Progress in retinal and …, 2020 - Elsevier
Contact lenses represent a widely utilized form of vision correction with more than 140
million wearers worldwide. Although generally well-tolerated, contact lenses can cause …

Environmentally controlled bacterial vesicle‐mediated export

N Orench‐Rivera, MJ Kuehn - Cellular microbiology, 2016 - Wiley Online Library
Over the past two decades, researchers studying both microbial and host cell communities
have gained an appreciation for the ability of bacteria to produce, regulate, and functionally …

Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity

MR Hendricks, LP Lashua, DK Fischer… - Proceedings of the …, 2016 - National Acad Sciences
Clinical observations link respiratory virus infection and Pseudomonas aeruginosa
colonization in chronic lung disease, including cystic fibrosis (CF) and chronic obstructive …

Pathogen-derived extracellular vesicle-associated molecules that affect the host immune system: an overview

ME Kuipers, CH Hokke, HH Smits… - Frontiers in …, 2018 - frontiersin.org
Recently, the interest in extracellular vesicles (EVs) released by pathogens like bacteria,
fungi, and parasites has rapidly increased. Many of these pathogens actively modulate the …

Prokaryotic membrane vesicles: new insights on biogenesis and biological roles

MF Haurat, W Elhenawy, MF Feldman - Biological chemistry, 2015 - degruyter.com
Biogenesis and trafficking of membrane vesicles are essential and well-studied processes in
eukaryotes. In contrast, vesiculation in bacteria is not well understood. Outer membrane …