Studying neuroanatomy using MRI

JP Lerch, AJW Van Der Kouwe, A Raznahan… - Nature …, 2017 - nature.com
The study of neuroanatomy using imaging enables key insights into how our brains function,
are shaped by genes and environment, and change with development, aging and disease …

[HTML][HTML] New insights into the dynamic development of the cerebral cortex in childhood and adolescence: Integrating macro-and microstructural MRI findings

LB Norbom, L Ferschmann, N Parker, I Agartz… - Progress in …, 2021 - Elsevier
Through dynamic transactional processes between genetic and environmental factors,
childhood and adolescence involve reorganization and optimization of the cerebral cortex …

Standardizing workflows in imaging transcriptomics with the abagen toolbox

RD Markello, A Arnatkeviciute, JB Poline, BD Fulcher… - elife, 2021 - elifesciences.org
Gene expression fundamentally shapes the structural and functional architecture of the
human brain. Open-access transcriptomic datasets like the Allen Human Brain Atlas provide …

A practical guide to linking brain-wide gene expression and neuroimaging data

A Arnatkevic̆iūtė, BD Fulcher, A Fornito - Neuroimage, 2019 - Elsevier
The recent availability of comprehensive, brain-wide gene expression atlases such as the
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …

A high-resolution in vivo atlas of the human brain's serotonin system

V Beliveau, M Ganz, L Feng, B Ozenne… - Journal of …, 2017 - Soc Neuroscience
The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain
functions and is critically involved in many neuropsychiatric disorders. Here, we present a …

Virtual histology of cortical thickness and shared neurobiology in 6 psychiatric disorders

Y Patel, N Parker, J Shin, D Howard, L French… - JAMA …, 2021 - jamanetwork.com
Importance Large-scale neuroimaging studies have revealed group differences in cortical
thickness across many psychiatric disorders. The underlying neurobiology behind these …

Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

J Sepulcre, MJ Grothe, F d'Oleire Uquillas… - Nature medicine, 2018 - nature.com
Tau and amyloid beta (Aβ) proteins accumulate along neuronal circuits in Alzheimer's
disease. Unraveling the genetic background for the regional vulnerability of these …

[HTML][HTML] Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortex

R Romero-Garcia, KJ Whitaker, F Váša, J Seidlitz… - Neuroimage, 2018 - Elsevier
Complex network topology is characteristic of many biological systems, including anatomical
and functional brain networks (connectomes). Here, we first constructed a structural …

[HTML][HTML] Connectome disconnectivity and cortical gene expression in patients with schizophrenia

IAC Romme, MA de Reus, RA Ophoff, RS Kahn… - Biological …, 2017 - Elsevier
Background Genome-wide association studies have identified several common risk loci for
schizophrenia (SCZ). In parallel, neuroimaging studies have shown consistent findings of …

Overcoming false-positive gene-category enrichment in the analysis of spatially resolved transcriptomic brain atlas data

BD Fulcher, A Arnatkeviciute, A Fornito - Nature communications, 2021 - nature.com
Transcriptomic atlases have improved our understanding of the correlations between gene-
expression patterns and spatially varying properties of brain structure and function. Gene …