Mesenchymal stem cells (MSCs) are progenitors of connective tissues, which have emerged
as important tools for tissue engineering due to their differentiation potential along various …

Oxygen radicals, or reactive oxygen species (ROS) act as primary or secondary messengers
to promote cell growth or death. Many instances demonstrate an important direct role of ROS …

Oxidative stress is considered causal of aging and pathological cell death, however, very
little is known about its function in the natural processes that support the formation of an …

Thioredoxin 2 (Trx-2) is a small redox protein containing the thioredoxin active site Trp-Cys-
Gly-Pro-Cys that is localized to the mitochondria by a mitochondrial leader sequence and …

The mitochondria, present in almost all eukaryotic cells, produce energy but also contribute
to many other essential cellular functions. One of the unique characteristics of the …

Reactive oxygen species (ROS), mostly derived from mitochondrial activity, can damage
various macromolecules and consequently cause cell death. This ROS activity has been …

Embryo development relies on the complex interplay of the basic cellular processes
including proliferation, differentiation and apoptotic cell death. Precise regulation of these …

Fatty acids are not only widely known as energy sources, but also play important roles in
many metabolic pathways. The significance of fatty acids in modulating the reproductive …

The murine gap junction protein connexin43 (Cx43) is expressed in blood vessels, with
vastly different contribution by endothelial and smooth muscle cells. We have used the Cre …

The actual role of programmed cell death (PCD) in embryonic processes and the extrinsic
signals that define the death fate in developing cells are still poorly understood. Here, we …