▪ Abstract Stably folded membrane proteins reside in a free energy minimum determined by
the interactions of the peptide chains with each other, the lipid bilayer hydrocarbon core, the …

The thermodynamic principles underlying the structural stability of membrane proteins are
difficult to obtain directly from whole proteins because of intractable problems related to …

Cytosolic transport is an essential requirement but a major obstacle to efficient delivery of
therapeutic peptides, proteins and nucleic acids. Current understanding of cytosolic delivery …

2 1 Introduction the most salient points are just that a molecule can exist in a variety of states
depending on how its electrons are distributed among a set of molecular orbitals, and that …

▪ Abstract Bacteriorhodopsin is the best understood ion transport protein and has become a
paradigm for membrane proteins in general and transporters in particular. Models up to 2.5 …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

▪ Abstract Helical membrane protein folding and oligomerization can be usefully
conceptualized as involving two energetically distinct stages—the formation and subsequent …

The second edition of this best-selling handbook is bigger, more comprehensive, and now
completely current. In addition to thorough updates to the discussions featured in the first …

The 101-residue monomeric protein S6 unfolds in the anionic detergent sodium dodecyl
sulfate (SDS) above the critical micelle concentration, with unfolding rates varying according …

A question of fundamental importance concerning the biosynthesis of integral membrane
proteins is whether transmembrane secondary structure can insert spontaneously into a lipid …