The reorganization of metabolic pathways in cancer facilitates the flux of carbon and
reducing equivalents into anabolic pathways at the expense of oxidative phosphorylation …

Introduction: Hepatocellular carcinoma (HCC) is one of the most common and lethal
cancers. Progress has been made in treatment of HCC; however, improved outcomes are …

Lysosomes have many roles, including degrading macromolecules and signalling to the
nucleus. Lysosomal dysfunction occurs in various human conditions, such as common …

The cytokine IFN-γ coordinates macrophage activation and is essential for control of
pathogens, including Mycobacterium tuberculosis. However, the mechanisms by which IFN …

Endocannabinoids are endogenous ligands of the cannabinoid receptors CB 1 and CB 2.
Two arachidonic acid derivatives, arachidonoylethanolamide (anandamide) and 2 …

Marijuana and aspirin have been used for millennia to treat a wide range of maladies
including pain and inflammation. Both cannabinoids, like marijuana, that exert anti …

Aberrant lipid metabolism is an established hallmark of cancer cells. In particular, ether lipid
levels have been shown to be elevated in tumors, but their specific function in cancer …

Invasive, site-specific metabolite information could be better obtained from tissues. Hence,
highly sensitive mass spectrometry-based metabolomics coupled with separation …

Bioactive N-acylethanolamines (NAEs) are ethanolamides of long-chain fatty acids,
including palmitoylethanolamide, oleoylethanolamide and anandamide. In animal tissues …

d-Serine is a brain-enriched d-amino acid that works as a transmitter-like molecule by
physiologically activating NMDA receptors. Synthesis of d-serine is carried out by serine …