Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

E Latacz, D Höppener, A Bohlok, S Leduc… - British journal of …, 2022 - nature.com
The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of
liver metastases were established in 2017. Since then, numerous studies have applied …

Liver immune microenvironment and metastasis from colorectal cancer-pathogenesis and therapeutic perspectives

X Zeng, SE Ward, J Zhou, ASL Cheng - Cancers, 2021 - mdpi.com
Simple Summary Liver metastasis remains the major contributor in colorectal cancer-related
death. It has become clear that the unique immune features of liver microenvironment take …

Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution

JR Fleischer, AM Schmitt, G Haas, X Xu, EM Zeisberg… - Molecular Cancer, 2023 - Springer
Background Colorectal cancer liver metastases (CRCLM) are associated with a poor
prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti …

Heterogeneity of primary and metastatic CAFs: From differential treatment outcomes to treatment opportunities

Z Kou, C Liu, W Zhang, C Sun… - … Journal of Oncology, 2024 - spandidos-publications.com
Compared with primary tumor sites, metastatic sites appear more resistant to treatments and
respond differently to the treatment regimen. It may be due to the heterogeneity in the …

Development and validation of genomic and epigenomic signatures associated with tumor immune microenvironment in hepatoblastoma

Y Zhang, T Zhang, Q Yin, H Luo - BMC cancer, 2021 - Springer
Background This study aimed to probe and verify aberrantly methylated and expressed
genes in hepatoblastoma and to analyze their interactions with tumor immune …

Compressive stress triggers fibroblasts spreading over cancer cells to generate carcinoma in situ organization

F Bertillot, L Andrique, C Ureña Martin, O Zajac… - Communications …, 2024 - nature.com
At the early stage of tumor progression, fibroblasts are located at the outer edges of the
tumor, forming an encasing layer around it. In this work, we have developed a 3D in vitro …

[HTML][HTML] Clinical implications and mechanism of histopathological growth pattern in colorectal cancer liver metastases

BT Kong, QS Fan, XM Wang, Q Zhang… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Liver is the most common site of metastases of colorectal cancer, and liver metastases
present with distinct histopathological growth patterns (HGPs), including desmoplastic …

Label-free multiphoton microscopy enables histopathological assessment of colorectal liver metastases and supports automated classification of neoplastic tissue

R Galli, T Siciliano, D Aust, S Korn, K Kirsche… - Scientific Reports, 2023 - nature.com
As the state of resection margins is an important prognostic factor after extirpation of
colorectal liver metastases, surgeons aim to obtain negative margins, sometimes elaborated …

Consideration on immunotherapy of liver metastases of malignant tumors

C Jiang, ZH Zhang, JX Li - World Journal of Gastrointestinal …, 2024 - pmc.ncbi.nlm.nih.gov
In this editorial, we comment on the article “Analysis of the impact of immunotherapy efficacy
and safety in patients with gastric cancer and liver metastasis” by Liu et al that was …

The histological growth patterns in liver metastases from colorectal cancer display differences in lymphoid, myeloid, and mesenchymal cells

G Garcia‐Vicién, N Ruiz, P Micke, JC Ruffinelli… - MedComm, 2024 - Wiley Online Library
Colorectal liver metastases grow following different histologic growth patterns (HGPs),
classified as desmoplastic and nondesmoplastic (dHGP, non‐dHGP), being the latter …