Mesenchymal stem cells (MSC) are a group of clonogenic cells present among the bone
marrow stroma and capable of multilineage differentiation into mesoderm-type cells such as …

Human aging is associated with bone loss leading to bone fragility and increased risk of
fractures. The cellular and molecular causes of age‐related bone loss are current intensive …

This review focuses on the interaction between multipotent stromal cells (MSCs) and
carcinoma and the possible use of MSCs in cell-based anticancer therapies. MSCs are …

Telomere length and cell function can be preserved by the human reverse transcriptase
telomerase (hTERT), which synthesizes the new telomeric DNA from a RNA template, but is …

Evolutionary theory predicts that cellular maintenance, stress defense, and DNA repair
mechanisms should be most active in germ line cells, including embryonic stem cells that …

In recent years, the potential of stem cell research for tissue engineering-based therapies
and regenerative medicine clinical applications has become well established. In 2006 …

The current review focuses on the connection of telomerase and telomeres with aging. In
this review, we describe the changes in telomerase and telomere length (TEL) during …

One of the hallmarks of advanced malignancies is continuous cell growth and this almost
universally correlates with the reactivation of telomerase. Although there is still much we do …

Telomeres are responsible for protecting chromosome ends in order to prevent the loss of
coding DNA. Their maintenance is required for achieving immortality by neoplastic cells and …

Background We previously reported the in vitro spontaneous transformation of human
mesenchymal stem cells (MSC) generating a population with tumorigenic potential, that we …