We are now near the top of the mitochondrial pathway of apoptosis, at the point before the
mitochondrial outer membrane permeabilizes to release proteins such as cytochrome c into …

Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal
and lysosomal compartments. It is involved in the turnover of intracellular and extracellular …

Type I photosensitization provides an effective solution to the problem of unsatisfactory
photodynamic therapeutic (PDT) effects caused by the tumor hypoxia. The challenge in the …

In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

Cysteine cathepsin protease activity is frequently dysregulated in the context of neoplastic
transformation. Increased activity and aberrant localization of proteases within the tumour …

It is more than 50years since the lysosome was discovered. Since then its hydrolytic
machinery, including proteases and other hydrolases, has been fairly well identified and …

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50
000 articles providing one or the other information about this pleiotropic cytokine or its …

The initial insight into the genetic basis of apoptosis, or programmed cell death, was gained
from ingenious studies of the roundworm Caenorhabditis elegans (for review, see Horvitz …