The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

Coordinated function of the innate and adaptive arms of the immune system in vertebrates is
essential to promote protective immunity and to avoid immunopathology. The Notch …

Glioblastoma, the most common and aggressive malignant brain tumor, is propagated by
stem-like cancer cells refractory to existing therapies. Understanding the molecular …

Notch signaling is known to regulate the proliferation and differentiation of intestinal stem
and progenitor cells; however, direct cellular targets and specific functions of Notch signals …

Dendritic cells (DCs) in tissues and lymphoid organs comprise distinct functional subsets
that differentiate in situ from circulating progenitors. Tissue-specific signals that regulate DC …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Proteins that engage in intracellular interactions with other proteins are widely considered
among the most biologically appealing yet chemically intractable targets for drug discovery …

Signaling through Notch receptors and their transcriptional effector RBP-J is essential for
lymphocyte development and function, whereas its role in other immune cell types is …

Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous
epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor …

Direct inhibition of transcription factor complexes remains a central challenge in the
discipline of ligand discovery. In general, these proteins lack surface involutions suitable for …