The development of disease-modifying therapies for osteoarthritis (DMOADs): the evidence to date
Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue
involvement of varying severity and no regulatory-agency-approved disease-modifying …
involvement of varying severity and no regulatory-agency-approved disease-modifying …
Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice
TJ Kaptchuk, CC Hemond, FG Miller - bmj, 2020 - bmj.com
Despite their ubiquitous presence, placebos and placebo effects retain an ambiguous and
unsettling presence in biomedicine. Specifically focused on chronic pain, this review …
unsettling presence in biomedicine. Specifically focused on chronic pain, this review …
Safety and efficacy of subcutaneous ianalumab (VAY736) in patients with primary Sjögren's syndrome: a randomised, double-blind, placebo-controlled, phase 2b …
Background Sjögren's syndrome is an autoimmune disease characterised by dry eyes and
mouth, systemic features, and reduced quality of life. There are no disease-modifying …
mouth, systemic features, and reduced quality of life. There are no disease-modifying …
Umbilical cord-derived mesenchymal stromal cells (MSCs) for knee osteoarthritis: repeated MSC dosing is superior to a single MSC dose and to hyaluronic acid in a …
J Matas, M Orrego, D Amenabar… - Stem cells …, 2019 - academic.oup.com
Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional
treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and …
treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and …
Effects of open-label placebos in clinical trials: a systematic review and meta-analysis
M von Wernsdorff, M Loef, B Tuschen-Caffier… - Scientific reports, 2021 - nature.com
Open-label placebos (OLPs) are placebos without deception in the sense that patients know
that they are receiving a placebo. The objective of our study is to systematically review and …
that they are receiving a placebo. The objective of our study is to systematically review and …
Arthroscopic surgery for degenerative knee: systematic review and meta-analysis of benefits and harms
Objective To determine benefits and harms of arthroscopic knee surgery involving partial
meniscectomy, debridement, or both for middle aged or older patients with knee pain and …
meniscectomy, debridement, or both for middle aged or older patients with knee pain and …
The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized …
L Shen, T Yuan, S Chen, X Xie, C Zhang - Journal of orthopaedic surgery …, 2017 - Springer
Background Quite a few randomized controlled trials (RCTs) investigating the efficacy of
platelet-rich plasma (PRP) for treatment of knee osteoarthritis (OA) have been recently …
platelet-rich plasma (PRP) for treatment of knee osteoarthritis (OA) have been recently …
Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
A Haroyan, V Mukuchyan, N Mkrtchyan… - … and alternative medicine, 2018 - Springer
Background The aim of this clinical trial was to assess the efficacy and safety of curcuminoid
complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its …
complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its …
Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of …
Objective Clinical guidelines recommend exercise as a core treatment for knee or hip
osteoarthritis (OA). However, how its analgesic effect compares to analgesics, for example …
osteoarthritis (OA). However, how its analgesic effect compares to analgesics, for example …
Clinical relevance of contextual factors as triggers of placebo and nocebo effects in musculoskeletal pain
G Rossettini, E Carlino, M Testa - BMC musculoskeletal disorders, 2018 - Springer
Placebo and nocebo effects are embodied psycho-neurobiological responses capable of
modulating pain and producing changes at different neurobiological, body at perceptual and …
modulating pain and producing changes at different neurobiological, body at perceptual and …