Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

In recent years there has been a growing interest among cancer biologists in cancer
metabolism. This Review summarizes past and recent advances in our understanding of the …

Gene transcription and cell metabolism are two fundamental biological processes that
mutually regulate each other. Upregulated or altered expression of glucose metabolic genes …

Cancer cells display a high rate of glycolysis in the presence of oxygen to promote
proliferation. Gluconeogenesis, the reverse pathway of glycolysis, can antagonize aerobic …

Cancer cells constantly face a fluctuating nutrient supply and interference with adaptive
responses might be an effective therapeutic approach. It has been discovered that in the …

Cancer cells often require glutamine for growth, thereby distinguishing them from most
normal cells. Here we show that PIK3CA mutations reprogram glutamine metabolism by …

Cancer cells adapt metabolically to proliferate under nutrient limitation. Here we used
combined transcriptional-metabolomic network analysis to identify metabolic pathways that …

Phosphoenolpyruvate carboxykinase (PEPCK) is well known for its role in gluconeogenesis.
However, PEPCK is also a key regulator of TCA cycle flux. The TCA cycle integrates …

The tricarboxylic acid (TCA) cycle is a central metabolic pathway responsible for supplying
reducing potential for oxidative phosphorylation and anabolic substrates for cell growth …