Activation and regulation of purinergic P2X receptor channels
Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
P2X receptors
RA North - … Transactions of the Royal Society B …, 2016 - royalsocietypublishing.org
Extracellular adenosine 5′-triphosphate (ATP) activates cell surface P2X and P2Y
receptors. P2X receptors are membrane ion channels preferably permeable to sodium …
receptors. P2X receptors are membrane ion channels preferably permeable to sodium …
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
P2X receptors are trimeric ATP-activated ion channels permeable to Na+, K+ and Ca2+. The
seven P2X receptor subtypes are implicated in physiological processes that include …
seven P2X receptor subtypes are implicated in physiological processes that include …
Signaling at purinergic P2X receptors
A Surprenant, RA North - Annual review of physiology, 2009 - annualreviews.org
P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X
receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of …
receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of …
Molecular and functional properties of P2X receptors—recent progress and persisting challenges
K Kaczmarek-Hájek, É Lörinczi, R Hausmann… - Purinergic …, 2012 - Springer
Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
P2X receptors in health and disease
G Burnstock, C Kennedy - Advances in pharmacology, 2011 - Elsevier
Seven P2X receptor subunits have been cloned which form functional homo-and
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …
Ligand-gated ion channels: new insights into neurological disorders and ligand recognition
1. INTRODUCTION Ligand-gated ion channels (LGICs) mediate intercellular communication
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
Molecular structure and function of P2X receptors
C Habermacher, K Dunning, T Chataigneau… - Neuropharmacology, 2016 - Elsevier
Abstract ATP-gated P2X receptors are trimeric ion channels selective to cations. Recent
progress in the molecular biophysics of these channels enables a better understanding of …
progress in the molecular biophysics of these channels enables a better understanding of …
Structural basis for the functional properties of the P2X7 receptor for extracellular ATP
The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional
properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family …
properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family …
Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions
S Roger, ZZ Mei, JM Baldwin, L Dong, H Bradley… - Journal of psychiatric …, 2010 - Elsevier
Genetic linkage studies have previously identified many single non-synonymous nucleotide
polymorphisms (SNPs) in the human P2RX7 gene in individuals with affective mood …
polymorphisms (SNPs) in the human P2RX7 gene in individuals with affective mood …