There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all
cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works …

Nitric oxide (NO) has long been known as endothelium-derived relaxing factor. It is a
vasodilator, modulating vascular tone, blood pressure and hemodynamics, a role exploited …

Lung ischemia-reperfusion injury remains one of the major complications after cardiac
bypass surgery and lung transplantation. Due to its dual blood supply system and the …

Monocytes and macrophages are central cells of the innate immune system, responsible for
defending against diverse pathogens. While they originate from a common myeloid …

Overexpression of alpha-synuclein and oxidative stress has been implicated in the neuronal
cell death in Parkinson's disease. Alpha-synuclein associates with mitochondria and …

Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction,
progressing eventually to the final end point heart failure (HF), remain the leading cause of …

To analyze the copper-induced cross talk among calcium, nitric oxide (NO), and hydrogen
peroxide (H2O2) and the calcium-dependent activation of gene expression, the marine alga …

Nitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous
pathological process, including cancer. Among the different pathways where NO has a …

Many degenerative disease processes associated with aging result from enhanced
extracellular matrix (ECM) breakdown. Concomitant with aberrant matrix destruction are …