Model‐informed drug development (MIDD) is a powerful quantitative approach that plays an
integral role in drug development and regulatory review. While applied throughout the life …

Summary The International Council for Harmonisation of Technical Requirements for
Pharmaceuticals for Human Use (ICH) E7, the guidance for the conduct of clinical trials in …

Importance Older age may be accompanied by changes in the pharmacokinetics or
pharmacodynamics or both of medications that can result in altered safety and efficacy …

Abstract The International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric
Committee aims to improve the use of drugs in older adults and develop new therapeutic …

The older population consisting of persons aged 65 years or older is the fastest-growing
population group and also the major consumer of pharmaceutical products. Due to the …

Inappropriate polypharmacy is highly prevalent among older adults and presents a
significant healthcare concern. Conducting medication reviews and implementing …

Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic dynamic
modeling approach that can be used to predict or retrospectively describe changes in drug …

Abstract Purpose of Review We provide a review of considerations when applying principles
of optimal pharmacotherapy to older adults with heart failure (HF), an analysis on the pivotal …

The aim of this study was to investigate whether interventions to discontinue or down‐titrate
heart failure (HF) pharmacotherapy are feasible and associated with risks in older people. A …

The aging processes alter the body's response to a medicine's pharmacokinetics,
pharmacodynamics, and susceptibility to adverse effects. In addition, older adults, especially …