[HTML][HTML] Animal models of shigellosis: a historical overview

N Alphonse, C Odendall - Current Opinion in Immunology, 2023 - Elsevier
Highlights•Intraperitoneal Shigella infection is often used but lacks physiological
relevance.•The zebrafish larvae model is best for imaging studies.•The streptomycin-Nlrc4 …

Recent advances in modelling Shigella infection

SL Miles, KE Holt, S Mostowy - Trends in Microbiology, 2024 - cell.com
Shigella is an important human-adapted pathogen which contributes to a large global
burden of diarrhoeal disease. Together with the increasing threat of antimicrobial resistance …

Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri

V Torraca, RJ White, IM Sealy… - Disease models & …, 2024 - journals.biologists.com
Shigella flexneri is a human-adapted pathovar of Escherichia coli that can invade the
intestinal epithelium, causing inflammation and bacillary dysentery. Although an important …

RpoS activates formation of Salmonella Typhi biofilms and drives persistence in the gall bladder

SK Desai, Y Zhou, R Dilawari, AL Routh, V Popov… - BioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
The development of strategies for targeting the asymptomatic carriage of Salmonella Typhi
in chronic typhoid patients has suffered owing to our basic lack of understanding of the …

Shigella Induces Pro-Inflammatory Macrophages that Cooperate with Neutrophils to Protect from Secondary Infection

MC Gomes, D Brokatzky, S Mostowy - Available at SSRN 4981730, 2024 - papers.ssrn.com
Shigella is an important human pathogen for which there is no effective vaccine. Although
decades of seminal work have shown that pathogenicity of Shigella relies on induction of …

RpoS activates Salmonella Typhi biofilms and drives persistence in a Zebrafish model.

SK Desai, Y Zhou, R Dilawari, AL Routh… - Biorxiv: the Preprint …, 2023 - europepmc.org
The development of strategies for targeting the asymptomatic carriage of Salmonella Typhi
in chronic typhoid patients has suffered owing to our basic lack of understanding of the …

Septins promote macrophage pyroptosis by regulating gasdermin D cleavage and ninjurin-1-mediated plasma membrane rupture

D Brokatzky, MC Gomes, S Robertin, C Albino… - Cell Chemical …, 2024 - cell.com
The septin cytoskeleton is primarily known for roles in cell division and host defense against
bacterial infection. Despite recent insights, the full breadth of roles for septins in host …