Antibodies and antibody-derived macromolecules have established themselves as the
mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure …

Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark
heavy‐chain antibodies, have many desirable properties as components of biologic drugs …

The B cell receptor and secreted antibody are at the nexus of humoral adaptive immunity. In
this review, we summarize what is known of the immunoglobulin genes of jawed …

Bispecific antibodies have moved from being an academic curiosity with therapeutic promise
to reality, with two molecules being currently commercialized (Hemlibra® and Blincyto®) …

Highlights•Camelids and sharks comprise heavy chain-only antibodies devoid of light
chains.•Their variable domains are able to address cryptic and recessed epitopes.•These …

The study was aimed to design fluoroquinolone (FQ) substitutes, improve the biological
metabolism and concentration ability of fluoroquinolones (FQs) drug from the perspective of …

In addition to antibodies with the classical composition of heavy and light chains, the
adaptive immune repertoire of sharks also includes a heavy-chain only isotype, where …

Single domain antibodies (sdAbs) are gaining a reputation as superior recognition elements
as they combine the advantages of the specificity and affinity found in conventional …

Shark is a cartilaginous fish that produces new antigen receptor (IgNAR) antibodies. This
antibody is identified with a similar human heavy chain but dissimilar sequences. The …

Cancer is a disease that evolves continuously with unpredictable outcomes. Although
conventional chemotherapy can display significant antitumor effects, the lack of specificity …