(S)-as well as (R)-mexiletine [1-(2, 6-dimethylphenoxy)-2-propanamine], a chiral orally
effective antiarrhythmic agent, was prepared by deracemization starting from the …

The voltage-gated sodium channels represent an important target for drug discovery since a
large number of physiological processes are regulated by these channels. In several …

Lewis acid catalyzed quaternary ammonium salt mediated highly regioselective ring-
opening of chiral activated aziridines and azetidines with alcohols to nonracemic β-and γ …

Optically active mexiletine analogues were synthesized and evaluated in vitro as use-
dependent blockers of skeletal muscle sodium channels. The mexiletine analogues were …

Mexiletine belongs to class IB antiarrhythmic drugs and it is still considered a drug of choice
for treating myotonias. However some patients do not respond to mexiletine or have …

Mexiletine [1-(2, 6-dimethylphenoxy)-2-propanamine], a chiral, orally effective antiarrhythmic
agent, and several analogues substituted on either the stereogenic centre or the xylyloxy …

A practical and efficient procedure for the enantioselective synthesis of mexiletine
analogues with use of 10% of spiroborate ester 6 as chirality transfer agent is presented. A …

Previously identified potent and/or use-dependent mexiletine (Mex) analogs were used as
template for the rational design of new Na v-channel blockers. The effects of the novel …

Background and purpose: Mexiletine (Mex), an orally effective antiarrhythmic agent used to
treat ventricular arrhythmias, has also been found to be effective for myotonia and …

Hydroxymethylmexiletine (HMM), one of the main metabolites of mexiletine, has been
synthesized in both racemic and optically active forms following two alternative routes. The …