Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …

Cytokines in CAR T cell–associated neurotoxicity

J Gust, R Ponce, WC Liles, GA Garden… - Frontiers in …, 2020 - frontiersin.org
Chimeric antigen receptor (CAR) T cells provide new therapeutic options for patients with
relapsed/refractory hematologic malignancies. However, neurotoxicity is a frequent, and …

Plasmodium asexual growth and sexual development in the haematopoietic niche of the host

K Venugopal, F Hentzschel, G Valkiūnas… - Nature Reviews …, 2020 - nature.com
Plasmodium spp. parasites are the causative agents of malaria in humans and animals, and
they are exceptionally diverse in their morphology and life cycles. They grow and develop in …

Severe malaria

NJ White - Malaria journal, 2022 - Springer
Severe malaria is a medical emergency. It is a major cause of preventable childhood death
in tropical countries. Severe malaria justifies considerable global investment in malaria …

Malaria pathogenesis

DA Milner - Cold Spring Harbor perspectives in …, 2018 - perspectivesinmedicine.cshlp.org
In the mosquito–human life cycle, the six species of malaria parasites infecting humans
(Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale wallickeri, Plasmodium …

The anatomy and immunology of vasculature in the central nervous system

P Mastorakos, D McGavern - Science immunology, 2019 - science.org
Barriers between circulation and the central nervous system (CNS) play a key role in the
development and modulation of CNS immune responses. Structural variations in the …

Update on malaria

R Varo, C Chaccour, Q Bassat - Medicina Clínica (English Edition), 2020 - Elsevier
Despite recent successful efforts to reduce the global malaria burden, this disease remains a
significant global health problem. Only in 2018, malaria caused 228 million clinical …

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Immune dynamics in the CNS and its barriers during homeostasis and disease

MW Buckley, DB McGavern - Immunological reviews, 2022 - Wiley Online Library
The central nervous system (CNS) has historically been viewed as an immunologically
privileged site, but recent studies have uncovered a vast landscape of immune cells that …

Diagnosis, treatment, and prevention of malaria in the US: a review

JP Daily, A Minuti, N Khan - Jama, 2022 - jamanetwork.com
Importance Malaria is caused by protozoa parasites of the genusPlasmodiumand is
diagnosed in approximately 2000 people in the US each year who have returned from …