Acute leukemia (AL) is a hematological malignancy, and the prognosis of most AL patients
hasn't improved significantly, particularly for relapsed or refractory (R/R) AL. Therefore, new …

Nicotinamide adenine dinucleotide (NAD) is increasingly recognized as an important
signaling molecule that affects numerous biological pathways. Thus, enzymes that …

The multidomain protein Vav1, in addition to promote the acquisition of maturation related
properties by normal hematopoietic cells, is a key player in the ATRA-and PMA-induced …

Retinoid X receptor (RXR) has been targeted for the chemoprevention and treatment of
cancer. To discover potential agents acting through RXRs, we utilized an RXR response …

6-Formylindolo (3, 2-b) carbazole (FICZ) is a photoproduct of tryptophan and an
endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was previously …

MAPK signaling is required for retinoic acid (RA)-triggered G 0 cell cycle arrest and cell
differentiation, but the mechanism is not well defined. In this study, RA is found to cause …

Acquired resistance through genetic mutations is a major obstacle in targeted cancer
therapy, but the underlying mechanisms are poorly understood. Here we studied …

Retinoic acid (RA) is known to regulate cell growth and differentiation. In HL-60 human
myeloblastic leukemia cells, it causes mitogen-activated protein kinase (MAPK) signaling …

All-trans retinoic acid (RA) and interferons (IFNs) have efficacy in treating certain leukemias
and lymphomas, respectively, motivating interest in their mechanism of action to improve …

Abstract Introduction EVI1 (MECOM)-positive acute myeloid leukemia (AML) cells have
shown in vitro sensitivity to all-trans-retinoic acid (ATRA) by inducing differentiation, cell …