Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that takes part in
many key redox reactions. NAD+ biosynthesis and NAD+-consuming enzymes have been …

In recent decades, oxidative stress has become a focus of interest in most biomedical
disciplines and many types of clinical research. Increasing evidence shows that oxidative …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the
clinical management of gout and conditions associated with hyperuricemia for several …

Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic
cardiovascular dysfunction also underscores the development of diabetic retinopathy …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Endothelial progenitor cells (EPCs) are essential in vasculogenesis and wound healing, but
their circulating and wound level numbers are decreased in diabetes. This study aimed to …

Independent of the severity of coronary artery disease, diabetic patients have an increased
risk of developing heart failure. This clinical entity has been considered to be a distinct …

Throughout the last 2 decades, experimental evidence from in vitro studies and preclinical
models of disease has demonstrated that reactive oxygen and nitrogen species, including …