Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Cancer is a complex disease whose outcome depends largely on the cross-talk between the
tumor and its microenvironment. Here, we review the evolution of the field of tumor …

Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast
cells form a heterogeneous population of immune cells with differences in their ultra …

Gastric cancer is diagnosed in nearly one million new patients each year and it remains the
second leading cause of cancer-related deaths worldwide. Although gastric cancer …

The use of various transgenic mouse models and analysis of human tumour biopsies has
shown that bone marrow-derived myeloid cells, such as macrophages, neutrophils …

In addition to malignant neoplastic cells, cancer tissues also include immune cells,
fibroblasts, and endothelial cells, including an abundant collection of growth factors …

Mast cells are unique tissue‐resident immune cells that secrete a diverse array of
biologically active compounds that can stimulate, modulate, or suppress the immune …

The tumor microenvironment (TME) represents a milieu that enables tumor cells to acquire
the hallmarks of cancer. The TME is heterogeneous in composition and consists of cellular …

Mast cells (MCs) play important roles in normal immune responses and pathological states.
The location of MCs on the boundaries between tissues and the external environment …

Cancer development is a multistep process characterized by genetic and epigenetic
alterations during tumor initiation and progression. The stromal microenvironment can …