Mechanisms regulating the CRISPR-Cas systems
M Zakrzewska, M Burmistrz - Frontiers in Microbiology, 2023 - frontiersin.org
The CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR
associated proteins) is a prokaryotic system that enables sequence specific recognition and …
associated proteins) is a prokaryotic system that enables sequence specific recognition and …
AcrPred: A hybrid optimization with enumerated machine learning algorithm to predict Anti-CRISPR proteins
CRISPR-Cas, as a tool for gene editing, has received extensive attention in recent years.
Anti-CRISPR (Acr) proteins can inactivate the CRISPR-Cas defense system during …
Anti-CRISPR (Acr) proteins can inactivate the CRISPR-Cas defense system during …
CRISPR-based approaches for gene regulation in non-model bacteria
SN Call, LB Andrews - Frontiers in genome editing, 2022 - frontiersin.org
CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) have become
ubiquitous approaches to control gene expression in bacteria due to their simple design and …
ubiquitous approaches to control gene expression in bacteria due to their simple design and …
CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYing
F Zhou, X Yu, R Gan, K Ren, C Chen… - Nucleic acids …, 2023 - academic.oup.com
The CRISPR-Cas system is a highly adaptive and RNA-guided immune system found in
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
[HTML][HTML] Thousands of small, novel genes predicted in global phage genomes
Summary Small genes (< 150 nucleotides) have been systematically overlooked in phage
genomes. We employ a large-scale comparative genomics approach to predict> 40,000 …
genomes. We employ a large-scale comparative genomics approach to predict> 40,000 …
Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution
Viruses in built environments (BEs) raise public health concerns, yet they are generally less
studied than bacteria. To better understand viral dynamics in BEs, this study assesses …
studied than bacteria. To better understand viral dynamics in BEs, this study assesses …
Anti-CRISPR prediction using deep learning reveals an inhibitor of Cas13b nucleases
KG Wandera, OS Alkhnbashi, H vI Bassett… - Molecular cell, 2022 - cell.com
As part of the ongoing bacterial-phage arms race, CRISPR-Cas systems in bacteria clear
invading phages whereas anti-CRISPR proteins (Acrs) in phages inhibit CRISPR defenses …
invading phages whereas anti-CRISPR proteins (Acrs) in phages inhibit CRISPR defenses …
AcrDB: a database of anti-CRISPR operons in prokaryotes and viruses
CRISPR–Cas is an anti-viral mechanism of prokaryotes that has been widely adopted for
genome editing. To make CRISPR–Cas genome editing more controllable and safer to use …
genome editing. To make CRISPR–Cas genome editing more controllable and safer to use …
Phages are unrecognized players in the ecology of the oral pathogen Porphyromonas gingivalis
Abstract Background Porphyromonas gingivalis (hereafter “Pg”) is an oral pathogen that has
been hypothesized to act as a keystone driver of inflammation and periodontal disease …
been hypothesized to act as a keystone driver of inflammation and periodontal disease …
AcrHub: an integrative hub for investigating, predicting and mapping anti-CRISPR proteins
Anti-CRISPR (Acr) proteins naturally inhibit CRISPR-Cas adaptive immune systems across
bacterial and archaeal domains of life. This emerging field has caused a paradigm shift in …
bacterial and archaeal domains of life. This emerging field has caused a paradigm shift in …