Parahydrogen‐based hyperpolarization for biomedicine

JB Hövener, AN Pravdivtsev, B Kidd… - Angewandte Chemie …, 2018 - Wiley Online Library
Magnetic resonance (MR) is one of the most versatile and useful physical effects used for
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …

Hyperpolarized NMR Spectroscopy: d‐DNP, PHIP, and SABRE Techniques

KV Kovtunov, EV Pokochueva… - Chemistry–An Asian …, 2018 - Wiley Online Library
The intensity of NMR signals can be enhanced by several orders of magnitude by using
various techniques for the hyperpolarization of different molecules. Such approaches can …

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research

J Kurhanewicz, DB Vigneron, K Brindle… - Neoplasia, 2011 - Elsevier
A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …

NMR hyperpolarization techniques for biomedicine

P Nikolaou, BM Goodson… - Chemistry–A European …, 2015 - Wiley Online Library
Recent developments in NMR hyperpolarization have enabled a wide array of new in vivo
molecular imaging modalities, ranging from functional imaging of the lungs to metabolic …

The theory and practice of hyperpolarization in magnetic resonance using parahydrogen

RA Green, RW Adams, SB Duckett, RE Mewis… - Progress in nuclear …, 2012 - Elsevier
NMR spectroscopy is arguably the most powerful and versatile analytical spectroscopic
method available to analyze nuclides which possess a magnetic dipole moment and …

ParaHydrogen Induced Polarization of 13C carboxylate resonance in acetate and pyruvate

F Reineri, T Boi, S Aime - Nature communications, 2015 - nature.com
The advent of nuclear spins hyperpolarization techniques represents a breakthrough in the
field of medical diagnoses by magnetic resonance imaging. Dynamic nuclear polarization …

Applications of NMR spectroscopy to systems biochemistry

TWM Fan, AN Lane - Progress in nuclear magnetic resonance spectroscopy, 2016 - Elsevier
The past decades of advancements in NMR have made it a very powerful tool for metabolic
research. Despite its limitations in sensitivity relative to mass spectrometric techniques, NMR …

Iridium N-Heterocyclic Carbene Complexes as Efficient Catalysts for Magnetization Transfer from para-Hydrogen

MJ Cowley, RW Adams, KD Atkinson… - Journal of the …, 2011 - ACS Publications
While the characterization of materials by NMR is hugely important in the physical and
biological sciences, it also plays a vital role in medical imaging. This success is all the more …

Instrumentation for hydrogenative parahydrogen-based hyperpolarization techniques

AB Schmidt, CR Bowers, K Buckenmaier… - Analytical …, 2022 - ACS Publications
The unique properties of the entangled, antisymmetric nuclear spin state of dihydrogen,
parahydrogen (pH2), has intrigued physicists, chemists, and other scientists for almost a …

Hyperpolarising pyruvate through signal amplification by reversible exchange (SABRE)

W Iali, SS Roy, BJ Tickner, F Ahwal… - Angewandte …, 2019 - Wiley Online Library
Hyperpolarisation methods that premagnetise agents such as pyruvate are currently
receiving significant attention because they produce sensitivity gains that allow disease …