The intracellular ATP-ribosyltransferases PARP1 and PARP2, contribute to DNA base
excision repair (BER) and DNA demethylation and have been implicated in epigenetic …

Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms
(MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment …

The preservation of genome integrity requires specialised DNA damage repair (DDR)
signalling pathways to respond to each type of DNA damage. A key feature of DDR is the …

Homologous recombination (HR) is critical for error-free repair of DNA double-strand breaks.
Chromatin loading of RAD51, a key protein that mediates the recombination, is a crucial step …

Poly (ADP‐ribose) polymerase 1 is a versatile enzyme that is deeply involved in diverse
cellular processes. It exerts influence on pivotal activities such as DNA repair, transcriptional …

Prostate cancer (PCa) progression is characterized by increased expression and
transcriptional activity of the androgen receptor (AR). In the advanced stages of prostate …

Summary Radiation sensitive 52 (RAD52) is an important factor for double-strand break
repair (DSBR). However, deficiency in vertebrate/mammalian Rad52 has no apparent …

Baicalin plays important roles in different types of cancer. A previous report showed that
baicalin attenuates cisplatin resistance in lung cancer. However, its mechanism remains …

As a type of protein post-translational modification, SUMOylation is the process that attaches
a small ubiquitin-like modifier (SUMO) to lysine residues of protein substrates. Not only do …

The system of base excision repair (BER) evolved to correct the most abundant DNA
damages in mammalian cells is the most essential for maintaining the genome integrity. The …