Potential antiviral action of alkaloids

FL Abookleesh, BS Al-Anzi, A Ullah - Molecules, 2022 - mdpi.com
Viral infections and outbreaks have become a major concern and are one of the main
causes of morbidity and mortality worldwide. The development of successful antiviral …

Following “the Roots” of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a …

E Cinosi, G Martinotti, P Simonato… - BioMed research …, 2015 - Wiley Online Library
The use of substances to enhance human abilities is a constant and cross‐cultural feature in
the evolution of humanity. Although much has changed over time, the availability on the …

Neurobiology of Kratom and its main alkaloid mitragynine

FW Suhaimi, NHM Yusoff, R Hassan, SM Mansor… - Brain research …, 2016 - Elsevier
Kratom or its main alkaloid, mitragynine is derived from the plant Mitragyna speciosa Korth
which is indigenous to Southeast Asian countries. This substance has become widely …

Mitragyna speciosa: Clinical, Toxicological Aspects and Analysis in Biological and Non-Biological Samples

V Meireles, T Rosado, M Barroso, S Soares… - Medicines, 2019 - mdpi.com
The abuse of psychotropic substances is a well-known phenomenon, and many of them are
usually associated with ancestral traditions and home remedies. This is the case of …

A systematic review of (pre) clinical studies on the therapeutic potential and safety profile of kratom in humans

E Prevete, KPC Kuypers, EL Theunissen… - Human …, 2022 - Wiley Online Library
Abstract Introduction Kratom (Mitragyna speciosa) is a tropical plant traditionally used as an
ethnomedicinal remedy for several conditions in South East Asia. Despite the increased …

Beneficial and adverse health effects of kratom (Mitragyna speciosa): a critical review of the literature

J Heywood, S Smallets, D Paustenbach - Food and Chemical Toxicology, 2024 - Elsevier
Abstract Used in Southeast Asia for generations, kratom gained popularity in the United
States and elsewhere over the past several decades. Derived from Mitragyna speciosa …

In vitro and in vivo pharmacology of kratom

T Hiranita, S Obeng, A Sharma, JL Wilkerson… - Advances in …, 2022 - Elsevier
Kratom products have been historically and anecdotally used in south Asian countries for
centuries to manage pain and opioid withdrawal. The use of kratom products has …

The trouble with kratom: analytical and interpretative issues involving mitragynine

DM Papsun, A Chan-Hosokawa… - Journal of analytical …, 2019 - academic.oup.com
Mitragynine is the primary active alkaloid in the leaves of the tropical tree Mitragyna
speciosa, and goes by the popular names “Kratom”, biak-biak and maeng da. Mitragynine is …

[HTML][HTML] An insight review on the neuropharmacological effects, mechanisms of action, pharmacokinetics and toxicity of mitragynine

NAK Annuar, UK Azlan, A Mediani, X Tong… - Biomedicine & …, 2024 - Elsevier
Mitragynine is one of the main psychoactive alkaloids in Mitragyna speciosa Korth.(kratom).
It has opium-like effects by acting on μ-, δ-, and κ-opioid receptors in the brain. The …

Pharmacokinetics of mitragynine, a major analgesic alkaloid in kratom (Mitragyna speciosa): A systematic review

K Ya, W Tangamornsuksan, CN Scholfield… - Asian journal of …, 2019 - Elsevier
Abstract Background and objective Kratom (Mitragyna speciosa) is a tropical tree found in
southern Thailand and northern states of the Malay Peninsula. Kratom is commercially …