Investigation of macromolecular structure and dynamics is fundamental to understanding
how macromolecules carry out their functions in the cell. Significant advances have been …

Large-scale conformational changes are essential to link protein structures with their
function at the cell and organism scale, but have been elusive both experimentally and …

Protein conformational changes are at the heart of cell functions, from signalling to ion
transport. However, the transient nature of the intermediates along transition pathways …

Torsion angles are the natural degrees of freedom of protein structures. The ability to
determine torsional variations corresponding to observed changes in Cartesian coordinates …

Evidence is emerging that the role of protein structure in disease needs to be rethought.
Sequence mutations in proteins are often found to affect the rate at which a protein switches …

Biomolecules such as proteins and nucleic acids are involved in all biological processes. As
they take part in these processes, biomolecules often undergo motions and changes in their …