Targeting cancer metabolism in the era of precision oncology

ZE Stine, ZT Schug, JM Salvino, CV Dang - Nature reviews Drug …, 2022 - nature.com
One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …

Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy

J Qu, FS Kalyani, L Liu, T Cheng… - Cancer …, 2021 - Wiley Online Library
Patient‐derived cancer cells (PDCs) and patient‐derived xenografts (PDXs) are often used
as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell …

Therapeutic potential and molecular mechanisms of mycophenolic acid as an anticancer agent

J Benjanuwattra, P Chaiyawat, D Pruksakorn… - European journal of …, 2020 - Elsevier
Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil (MMF), an
immunosuppressive drug approved for the prophylaxis of allograft rejection in transplant …

Immunotherapy for hepatocellular carcinoma recurrence after liver transplantation, can we harness the power of immune checkpoint inhibitors?

J Jiang, H Huang, R Chen, Y Lin, Q Ling - Frontiers in Immunology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death
globally and liver transplantation (LT) can serve as the best curative treatment option …

Current trends and characteristics of hepatocellular carcinoma in patients with autoimmune liver diseases

EI Rigopoulou, GN Dalekos - Cancers, 2021 - mdpi.com
Simple Summary While hepatocellular carcinoma (HCC) is inextricably linked to underlying
cirrhosis due to chronic viral hepatitis, alcohol consumption, and non-alcoholic fatty liver …

[HTML][HTML] Tumor organoids for primary liver cancers: A systematic review of current applications in diagnostics, disease modeling, and drug screening

AA Qureshi, CJ Wehrle, S Ferreira-Gonzalez, C Jiao… - JHEP Reports, 2024 - Elsevier
Background & Aims Liver cancer-related deaths are projected to exceed one million
annually by 2030. Existing therapies have significant limitations, including severe side …

[HTML][HTML] Leveraging patient-derived organoids for personalized liver cancer treatment

J Rao, C Song, Y Hao, Z Chen, S Feng… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Primary liver cancer (PLC) is a primary cause of cancer-related death worldwide, and novel
treatments are needed due to the limited options available for treatment and tumor …

[HTML][HTML] KASL clinical practice guidelines for management of autoimmune hepatitis 2022

Korean Association for the Study of the … - Clinical and …, 2023 - ncbi.nlm.nih.gov
Autoimmune hepatitis (AIH) is an inflammatory liver disease of unknown etiology caused by
an autoimmune mechanism. It can occur in all age groups and manifest as almost every type …

Nanoparticle formulation of mycophenolate mofetil achieves enhanced efficacy against hepatocellular carcinoma by targeting tumour‐associated fibroblast

Z Yang, L Zhang, H Zhu, K Zhou… - Journal of Cellular …, 2021 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most aggressive tumours with marked fibrosis.
Mycophenolate mofetil (MMF) was well‐established to have antitumour and anti‐fibrotic …

Doxorubicin hydrochloride enhanced antitumour effect of CEA‐regulated oncolytic virotherapy in live cancer cells and a mouse model

B Xiao, C Ying, Y Chen, F Huang… - Journal of Cellular …, 2020 - Wiley Online Library
Oncolytic adenovirus (OA) has attracted increasing attention due to their specific
proliferation in tumour cells and resulting in lysis of tumour cells. To further improve the …