Cardiac hypertrophy is an adaptive response to abnormal physiological and pathological
stimuli, which can be classified into concentric and eccentric hypertrophy, induced by …

Traditionally, the evaluation of cardiac function has focused on systolic function; however,
there is a growing appreciation for the contribution of diastolic function to overall cardiac …

Cardiac contraction is the result of integrated cellular, tissue and organ function. Biophysical
in silico cardiac models offer a systematic approach for studying these multi-scale …

Aims While global longitudinal strain (GLS) is considered to be a sensitive marker of left
ventricular (LV) function, it is significantly influenced by loading conditions. We hypothesized …

Background Longitudinal strain (LS) is a sensitive marker of systolic function. Recent
findings suggest that both myocardial contractility and loading conditions determine LS. The …

Although women are more susceptible to pulmonary arterial hypertension (PAH) than men,
their right ventricular (RV) function is better preserved. Estrogen receptor-α (ERα) has been …

Background: Recent evidences suggest that sex hormones may be involved in the
regulation of exercise-induced left ventricular (LV) hypertrophy. However, the sex-specific …

Investigating the effect of sex on pressure unloading therapy in a clinical scenario is limited
by several nonstandardized factors. Hence, we sought to study sex-related similarities and …

The aim of the present study was to examine the role of sirtuin 3 (Sirt3)-autophagy in
regulating myocardial energy metabolism and inhibiting myocardial hypertrophy in …

With severe right ventricular (RV) pressure overload, women demonstrate better clinical
outcomes compared with men. The mechanoenergetic mechanisms underlying this …