Recent development of innovative tools for live imaging of actin filaments (F-actin) enabled
the detection of surprising nuclear structures responding to various stimuli, challenging …

The nucleus is a dynamic environment containing chromatin, membraneless organelles,
and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA …

In cardiovascular tissues, changes in the mechanical properties of the extracellular matrix
are associated with cellular de-differentiation and with subsequent functional declines …

Abstract During transcription, RNA Polymerase II (RNAPII) is spatially organised within the
nucleus into clusters that correlate with transcription activity. While this is a hallmark of …

In eukaryotic cells, the nucleus houses the genomic material of the cell. The physical
properties of the nucleus and its ability to sense external mechanical cues are tightly linked …

Background Nuclear lamins are type V intermediate filament proteins that maintain nuclear
structure and function. Furthermore, Emerin-an interactor of Lamin A/C, facilitates crosstalk …

A number of studies across different model systems revealed that chromatin undergoes
significant changes in dynamics in response to DNA damage. These include local motion …

The actin cytoskeleton is of fundamental importance for numerous cellular processes,
including intracellular transport, cell plasticity, and cell migration. However, functions of …

In the present day, it is possible to incorporate targeted mutations or replace a gene using
genome editing techniques such as customisable CRISPR/Cas9 system. Although induction …

In eukaryotic cells, most of the genetic material is contained within a highly specialized
organelle—the nucleus. A large body of evidence indicates that, within the nucleus …